There is no need to use over 25 mgs irregardless of your bodyweight. The thing is that it is about your receptor sensitivity, and not about your mass. If you take one small bodybuilder and a bigger one, the maximum difference in dosages that one should consider is like 10%, which is not worth all the trouble. So the dosage will be the same for you, even though you are a big guy. And it is pointless to use over 25 mgs of Ostarine, as the additional benefits will be minimal, so it will be a waste of the compound.