The asprin throws in a prostagladin that keeps the E working longer. So first thing in the morning you go 25E, 200C and 2 full asprins. IF you want to do this again at lunch then you do not need asprin, as it is still in your system. I would not do this a third time in one day. If you feel that this is not enough then you follow the same regimen,but use 50mg E, 200C and 2 full asprin in the morning and then at lunch your choice...25 or 50mgE, 200C. One you have the 2 full asprins in you then you are good for about 6 hours.