500 is perfectly fine and effective... some users have see diarrhea if they go to 1000-1500
heres an article for you to read
A dose-response study of TUDCA tested doses of 500 mg, 1000 mg, and 1500 mg per day over six months, finding that there was little difference between the doses on liver markers [50].
One study suggested 60 mg/kg/day as a tolerable and administrable dose for humans [52].
TUDCA taken at 10 ? 13 mg daily for three months is able to reduce liver enzyme levels [2].
Scientists used 15 ? 20 mg/kg body weight of TUDCA for improving bile salt composition [53].
In otherwise healthy obese persons, doses of 1,750 mg daily have been tolerated for up to four weeks [49].
In liver transplant patients, 500 mg of TUDCA taken daily for one year was not associated with any adverse effects [54].
In patients with PBC, 750 mg of TUDCA daily for two months was well-tolerated. Another study in patients with PBC found 1500 mg of TUDCA daily for six months was also well-tolerated [53, 3].
