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By: Dylan Gemelli
Proviron is the brand name for the orally applicable androgen and DHT (dihydrotestosterone) derivative termed Mesterolone. Roughly 5% of testosterone undergoes 5-alpha reduction to form the potent androgen DHT, which is a sex hormone and androgen hormone. DHT plays a major role in the formation of the male genitals, and, in adults, it acts as the primary androgen in the prostate and hair follicles. Proviron is one of the purest DHT hormones available. With DHT compounds like proviron, there is no concern for estrogen conversion. Proviron is often said to be like "Oral Master." It is important to remember that DHT is 3 to 4 times as androgenic as testosterone and is incapable of forming estrogen. Proviron is quite unique in that a simple look at its 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals steroids are. Proviron does have a 1-methyl group added to its structure.
Medical uses
Studies have shown proviron to be effective for depression, anxiety and to boost lack of sex drive. It would make sense that those with bipolar, unipolar, and dysthymia would benefit from this hormone. It’s generally prescribed by doctors to men with low libido. In addition, it’s a precursor to full TRT (testosterone replacement therapy).
Bodybuilding
Proviron became mainstream many years ago as an anti-estrogen because it is has a high affinity to bind to the aromatase enzyme. Steroid users began to use it to serve as theirs AI (aromatase inhibitor) replacement. Bodybuilders were also using it during post cycle therapy (PCT). Unfortunately, studies have shown proviron can suppress LH (luteinizing hormone) in some instances. As a result, high proviron dosage can prevent the pituitary gland from recovering after a steroid cycle. Some users insist proviron does not suppress the HPTA when used in PCT or during a bridge; however, this is up for debate. Some studies support long term use of proviron at high dosages without serious suppression. The science supports proviron use for PCT but not in every case.
I am a believer in proviron in any circumstance when ran responsibly. Dosing 50 mg per day has never shown me any sort of suppression whatsoever. I believe proviron has a place on cycle, in post cycle, in a bridge or at any time. It is just like any other concept, when abused, it can be detrimental but if ran properly, can yield excellent benefit.
Side Effects
Being that proviron is such a pure DHT derivative, we can logically say that it comes with sides, just like any other anabolic steroid. However, the side effects come from its DHT characteristics, so you can expect male pattern baldness issues, especially if you are prone to it. This is why those that choose DHT compounds and suffer from hair issues will run a 5alpha reductase inhibitor such as finasteride, or dutasteride, to counteract this side effect. DHT’s can also enlarge the prostate, but this is generally only in those that abuse them. As mentioned above, proviron is not a c17 alpha-alkylated compound, so liver problems are not an issue with it.
Being a DHT-based compound, Proviron is not going to be great for female athletes to use. Virilization (development of male sexual characteristics) is going to be a concern for women daring enough to try proviron. My advice is that there is much better, safer compounds for female athletes and bodybuilders to use.
Benefits of proviron use:
Proviron carries a variety of benefits and it serves well in a multitude of circumstances. Proviron is THE ULTIMATE COMPLIMENTARY compound. It really does not show a lot as a stand alone but when ran in conjunction with other compounds, it brings out the very best in them.
A large benefit of proviron use is that it binds very well to SHBG (sex hormone binding globulin), which is the hormone responsible for reducing free testosterone circulating in the body. This is probably the reason why some use proviron during PCT.
Those that compete will appreciate proviron’s hardening properties. Since proviron is 5-alpha reduced and not capable of forming estrogen, it will help give a drier look.
Androgen Receptors are found in fat cells as well as muscle cells and while they act on the AR in muscle cells to promote growth, they also act directly on the AR in fat cells to affect fat burning. The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue. As if thats not enough good news, some steroids (notably, testosterone) even increase the numbers of A.R. in muscle and fat. Thus, if you are taking a simple stack of proviron and testosterone, you’ll have more of the test you shoot as free testosterone floating around building muscle (compliments of the Proviron), more androgen receptors to be bound to (compliments of your testosterone) by your Proviron, thus causing more fat loss. Testosterone and Proviron are a very nice synergistic stack of an oral and injectable, because both drugs will actually act to enhance the effect of the other.
What we have here is a steroid which can basically make other steroids more effective by preventing their conversion into estrogen, as well as increasing the amount of circulating free testosterone in your body. This of course all provides a more hardened and quality look to muscles. Proviron is very much a "synergistic" drug in this respect, and its inclusion in any cycle would definitely make all of the other steroids perform better, and provide better gains. This is all compounded by the fact that proviron is a very lipolytic (fat-burning) drug.
Dosing:
Proviron has a place in any scenario and cycle. There are large amounts of benefits with very minimal side effects with use. The sweet spot for proviron dosing is 50 mg per day and no suppression should be seen with this amount. It can be ran safely at 100 mg per day but there could be signs of small side effects, including suppression at this dose.
Proviron (Mesterolone) Profile
- [1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one]
Molecular Weight: 304.4716
Molecular Formula: C20H32O2
Melting Point: N/A
Manufacturer: Schering
Release Date: 1960
Effective Dose: 25-200mgs/day
Active Life: up to 12 hours
Detection Time: 5-6weeks
Androgenic: Anabolic Ratio:30-40/100-150
Proviron is the brand name for the orally applicable androgen and DHT (dihydrotestosterone) derivative termed Mesterolone. Roughly 5% of testosterone undergoes 5-alpha reduction to form the potent androgen DHT, which is a sex hormone and androgen hormone. DHT plays a major role in the formation of the male genitals, and, in adults, it acts as the primary androgen in the prostate and hair follicles. Proviron is one of the purest DHT hormones available. With DHT compounds like proviron, there is no concern for estrogen conversion. Proviron is often said to be like "Oral Master." It is important to remember that DHT is 3 to 4 times as androgenic as testosterone and is incapable of forming estrogen. Proviron is quite unique in that a simple look at its 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals steroids are. Proviron does have a 1-methyl group added to its structure.
Medical uses
Studies have shown proviron to be effective for depression, anxiety and to boost lack of sex drive. It would make sense that those with bipolar, unipolar, and dysthymia would benefit from this hormone. It’s generally prescribed by doctors to men with low libido. In addition, it’s a precursor to full TRT (testosterone replacement therapy).
Bodybuilding
Proviron became mainstream many years ago as an anti-estrogen because it is has a high affinity to bind to the aromatase enzyme. Steroid users began to use it to serve as theirs AI (aromatase inhibitor) replacement. Bodybuilders were also using it during post cycle therapy (PCT). Unfortunately, studies have shown proviron can suppress LH (luteinizing hormone) in some instances. As a result, high proviron dosage can prevent the pituitary gland from recovering after a steroid cycle. Some users insist proviron does not suppress the HPTA when used in PCT or during a bridge; however, this is up for debate. Some studies support long term use of proviron at high dosages without serious suppression. The science supports proviron use for PCT but not in every case.
I am a believer in proviron in any circumstance when ran responsibly. Dosing 50 mg per day has never shown me any sort of suppression whatsoever. I believe proviron has a place on cycle, in post cycle, in a bridge or at any time. It is just like any other concept, when abused, it can be detrimental but if ran properly, can yield excellent benefit.
Side Effects
Being that proviron is such a pure DHT derivative, we can logically say that it comes with sides, just like any other anabolic steroid. However, the side effects come from its DHT characteristics, so you can expect male pattern baldness issues, especially if you are prone to it. This is why those that choose DHT compounds and suffer from hair issues will run a 5alpha reductase inhibitor such as finasteride, or dutasteride, to counteract this side effect. DHT’s can also enlarge the prostate, but this is generally only in those that abuse them. As mentioned above, proviron is not a c17 alpha-alkylated compound, so liver problems are not an issue with it.
Being a DHT-based compound, Proviron is not going to be great for female athletes to use. Virilization (development of male sexual characteristics) is going to be a concern for women daring enough to try proviron. My advice is that there is much better, safer compounds for female athletes and bodybuilders to use.
Benefits of proviron use:
Proviron carries a variety of benefits and it serves well in a multitude of circumstances. Proviron is THE ULTIMATE COMPLIMENTARY compound. It really does not show a lot as a stand alone but when ran in conjunction with other compounds, it brings out the very best in them.
A large benefit of proviron use is that it binds very well to SHBG (sex hormone binding globulin), which is the hormone responsible for reducing free testosterone circulating in the body. This is probably the reason why some use proviron during PCT.
Those that compete will appreciate proviron’s hardening properties. Since proviron is 5-alpha reduced and not capable of forming estrogen, it will help give a drier look.
Androgen Receptors are found in fat cells as well as muscle cells and while they act on the AR in muscle cells to promote growth, they also act directly on the AR in fat cells to affect fat burning. The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue. As if thats not enough good news, some steroids (notably, testosterone) even increase the numbers of A.R. in muscle and fat. Thus, if you are taking a simple stack of proviron and testosterone, you’ll have more of the test you shoot as free testosterone floating around building muscle (compliments of the Proviron), more androgen receptors to be bound to (compliments of your testosterone) by your Proviron, thus causing more fat loss. Testosterone and Proviron are a very nice synergistic stack of an oral and injectable, because both drugs will actually act to enhance the effect of the other.
What we have here is a steroid which can basically make other steroids more effective by preventing their conversion into estrogen, as well as increasing the amount of circulating free testosterone in your body. This of course all provides a more hardened and quality look to muscles. Proviron is very much a "synergistic" drug in this respect, and its inclusion in any cycle would definitely make all of the other steroids perform better, and provide better gains. This is all compounded by the fact that proviron is a very lipolytic (fat-burning) drug.
Dosing:
Proviron has a place in any scenario and cycle. There are large amounts of benefits with very minimal side effects with use. The sweet spot for proviron dosing is 50 mg per day and no suppression should be seen with this amount. It can be ran safely at 100 mg per day but there could be signs of small side effects, including suppression at this dose.
Proviron (Mesterolone) Profile
- [1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one]
Molecular Weight: 304.4716
Molecular Formula: C20H32O2
Melting Point: N/A
Manufacturer: Schering
Release Date: 1960
Effective Dose: 25-200mgs/day
Active Life: up to 12 hours
Detection Time: 5-6weeks
Androgenic: Anabolic Ratio:30-40/100-150
By : Dylan Gemelli
