Think of it in the most basic of terms bro, you're literally shoving a needle in your body somewhere and introducing a foreign substance to it and leaving it in there to dissipate after removing the syringe. There's something there that wasn't before taking up some space so you'll have some discomfort. Now consider the amount and concentration of active hormone. The higher the concentration, typically the more PIP due to super solvents, BA, etc...
So the wise Jedi recruit should definitely take all that into account on his/her quest to become super human. Just do The 44 one favor, by choosing this route of enhancement... make the most out of it. Nothing quite gets under my skin more than someone who's on this journey turning around and looking like they hobby lift 5 years down the road. #UsetheMirror