you can do whatever you want.. the last thing you want to do with mk677 is go low carb, regardless of the dosage but you can certainly do some trial and error on yourself if you are intent.. noone's guidance here is Gospel however given that i have been coaching it well over a decade, i know what comes along with it.. by all means try it out if you are intentWell if you go low carbs can't you just lower the dosage? I have found some 10mg or 15mg, I liked those because I allowed me to take 10mg, 15, 20, or 25, depending on how much I ate and how I felt