In the spirit of our academic pursuit for new insights regarding our favourite compounds, iSARMs forum gives you the second installation - featuring MK-677. Some of these effects may be known to you, but the more medical information is made clear, the more certainty we have with respect to the compounds' effects.
Disclaimer: If you choose to supplement with a given compound, ultimately, the responsibility is on you to make sure you are well informed. This author feels that there is no substitute to making decisions based on guidelines set by professionals with experience using MK-677.
A human study investigating 123 patients, all having hip fractures were dosed with MK-677. Hip fracture are notoriously known to be some of the most complex fractures with respect to healing and limitations, often leaving patients with a measure of life long debilitation. This human study has undeniably demonstrated that when a subset of patients were medicated with 25mg/day of MK-677 for 24 weeks, patients displayed significantly accelerated recovery and bone density restoration secondary to rapid healing of the bone matrix[SUB](1)[/SUB].
Yet another human study, following up on healthy patients in the ages of 60-81 dosing with 25mg/day of MK-677 for 1 year and 2 years, has shown the following dramatic effect on the physiology of aging:
- Significantly increased serum levels of IGF-I and GH
- Recomposition of fat to lean muscle ratio
- Increased in limb mass without exercise
- Reduced age related muscle wasting (sarcopenia)[SUB](2)[/SUB]
- Improvement in muscle strength and function without exercise
- Increase in body hydration at the cellular level
- Redistribution of abdominal fat deposits to subcutaneous fat (i.e. “bad kind” to “good kind”)
- Reduction of LDL cholesterol levels in the blood without dietary alterations
- Increase in Hemoglobin serum concentration [SUB](3)(4)[/SUB]
Recently, researchers were able to identify that the cells lining the blood vessels as well as the inner layers of the heart (endothelial cells), that require repair throughout our lifetime, also have stem cells that form them. Sadly, those stem cells become less and less potent as we age, losing the ability to fix the walls of the blood vessels and the heart.
Application of MK-677 suggested that these stem cells were able to maintain their regenerative capacity, essentially rendering your cardiovascular system...Ageless...[SUB](5)[/SUB]
It is commonly observed that over aging, the entire endocrine (hormonal) spectrum of the human body slowly changes. Whereas one can consider supplementing each hormone as it declines, such as Testosterone, Thyroid hormone, GH, IGF-I Calcitonin, Aldosterone et cetera – the quintessential issue is - we would have to inject numerous substances over our lifetime in a non sustainable way.
MK-677, in that respect, seems to address the issue as the grand maestro of our endocrine axis, and instead of being a specific substitute to a declining hormone, it works on a conglomerate of receptors within the central nervous system, resetting the entire pulsatile and reactive secretory functions[SUB](6)(7)(8)(9)(10)(11)(12)(13)[/SUB] of many hormones. In that respect, MK-677 not only has the ability to restore our hormonal status to its former days of glory, it does so in the physiological proportions each individual has within his own genetic blueprint, in a harmonious fashion[SUB](14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)[/SUB].
I've seen this question been asked numerous times, with many possible answers, albeit with poor explanation or supporting reasoning. Let's put the oral versos injectable application aside, I doubt you guys mind the needles. In this scenario, it's quite likely that experience alone would not suffice, since the observed effects seem to be quite similar between MK-677 and hGH. Scientifically, however, this couldn't be further from the truth. This is the idea of upstream mechanism effect (try to bear with me on this).
Imagine your car engine getting a lot of milage, combustion rates in the cylinders are uneven, oil leaks and oil pressure drops occur, the joints and bolts rust, et cetera. Of course, you can replace pistons, valves and engine blocks, pieces here and there... Or alternately – replace the engine, solve the problem upstream of the component causing the mechanical fault
Wheres hGH is a puzzle piece that causes specific anti-aging effect, MK-677 operates at an upstream higher level. MK-677 has the benefit of influencing the production of hGH, as well as dozens of other hormones, via mechanisms we employ naturally as humans. It "reteaches" the body how to reconsttitute the physiologically, naturally occurring endocrine (hormonal) axis as a whole. This allows MK-677 to direct the body to resume natural synthesis and secretion of the substances whose effect we can get by injecting them separately. Yet another difference, is that the alterations of physiology resulting from MK-677 applications are speculated to be long lasting past the last administration, since we are not simply supplementing one puzzle piece, we're directing the very hand that puts all the pieces together.
Any and all feedback is greatly appreciated.
Thanks for reading, and please supplement responsively.
References follow in the immediate post
Disclaimer: If you choose to supplement with a given compound, ultimately, the responsibility is on you to make sure you are well informed. This author feels that there is no substitute to making decisions based on guidelines set by professionals with experience using MK-677.
MK-677 has displayed the phenomenal ability to dramatically help heal fractured bones
A human study investigating 123 patients, all having hip fractures were dosed with MK-677. Hip fracture are notoriously known to be some of the most complex fractures with respect to healing and limitations, often leaving patients with a measure of life long debilitation. This human study has undeniably demonstrated that when a subset of patients were medicated with 25mg/day of MK-677 for 24 weeks, patients displayed significantly accelerated recovery and bone density restoration secondary to rapid healing of the bone matrix[SUB](1)[/SUB].
MK-677 has been shown to reverse crucial parameters of aging in humans
As we age, the physiology of our body changes. We develop decreased sensations for thirst and appetite, the body's response to anabolic hormones and insulin dwindles down, we utilize nutrient less efficiently, as well as Protein Energy Wasting throughout the entire body. Yet another human study, following up on healthy patients in the ages of 60-81 dosing with 25mg/day of MK-677 for 1 year and 2 years, has shown the following dramatic effect on the physiology of aging:
- Significantly increased serum levels of IGF-I and GH
- Recomposition of fat to lean muscle ratio
- Increased in limb mass without exercise
- Reduced age related muscle wasting (sarcopenia)[SUB](2)[/SUB]
- Improvement in muscle strength and function without exercise
- Increase in body hydration at the cellular level
- Redistribution of abdominal fat deposits to subcutaneous fat (i.e. “bad kind” to “good kind”)
- Reduction of LDL cholesterol levels in the blood without dietary alterations
- Increase in Hemoglobin serum concentration [SUB](3)(4)[/SUB]
MK-677 can help repair the aging heart and the aging blood vessels
The vast human cardiovascular network of arteries, veins and capillaries constantly requires repair and maintenance. In the recent past the medical field has identified the presence of stem cells, cells that show the ability to constantly regenerate and form brand new cells and tissues. Recently, researchers were able to identify that the cells lining the blood vessels as well as the inner layers of the heart (endothelial cells), that require repair throughout our lifetime, also have stem cells that form them. Sadly, those stem cells become less and less potent as we age, losing the ability to fix the walls of the blood vessels and the heart.
Application of MK-677 suggested that these stem cells were able to maintain their regenerative capacity, essentially rendering your cardiovascular system...Ageless...[SUB](5)[/SUB]
MK-677 has demonstrated the capacity to prevent death of heart muscle cells
Various receptor arrays present within the heart muscle cells, for reasons remaining unknown to us, respond to MK-677 unambiguously, causing a cardioprotective (heart preserving) effect on heart muscle cells. This has been speculated to be clinically relevant to prevent cellular death (termed "apoptosis") post heart attack, ischemia (blood depravation), loss of contractile force of heart muscle cells and possibly heart failure[SUB](28)[/SUB].MK-677 has demonstrated the ability to completely restructure your body's hormonal axis
It is commonly observed that over aging, the entire endocrine (hormonal) spectrum of the human body slowly changes. Whereas one can consider supplementing each hormone as it declines, such as Testosterone, Thyroid hormone, GH, IGF-I Calcitonin, Aldosterone et cetera – the quintessential issue is - we would have to inject numerous substances over our lifetime in a non sustainable way.
MK-677, in that respect, seems to address the issue as the grand maestro of our endocrine axis, and instead of being a specific substitute to a declining hormone, it works on a conglomerate of receptors within the central nervous system, resetting the entire pulsatile and reactive secretory functions[SUB](6)(7)(8)(9)(10)(11)(12)(13)[/SUB] of many hormones. In that respect, MK-677 not only has the ability to restore our hormonal status to its former days of glory, it does so in the physiological proportions each individual has within his own genetic blueprint, in a harmonious fashion[SUB](14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)[/SUB].
Why should I choose MK-677 over hGH?
I've seen this question been asked numerous times, with many possible answers, albeit with poor explanation or supporting reasoning. Let's put the oral versos injectable application aside, I doubt you guys mind the needles. In this scenario, it's quite likely that experience alone would not suffice, since the observed effects seem to be quite similar between MK-677 and hGH. Scientifically, however, this couldn't be further from the truth. This is the idea of upstream mechanism effect (try to bear with me on this).
Imagine your car engine getting a lot of milage, combustion rates in the cylinders are uneven, oil leaks and oil pressure drops occur, the joints and bolts rust, et cetera. Of course, you can replace pistons, valves and engine blocks, pieces here and there... Or alternately – replace the engine, solve the problem upstream of the component causing the mechanical fault
Wheres hGH is a puzzle piece that causes specific anti-aging effect, MK-677 operates at an upstream higher level. MK-677 has the benefit of influencing the production of hGH, as well as dozens of other hormones, via mechanisms we employ naturally as humans. It "reteaches" the body how to reconsttitute the physiologically, naturally occurring endocrine (hormonal) axis as a whole. This allows MK-677 to direct the body to resume natural synthesis and secretion of the substances whose effect we can get by injecting them separately. Yet another difference, is that the alterations of physiology resulting from MK-677 applications are speculated to be long lasting past the last administration, since we are not simply supplementing one puzzle piece, we're directing the very hand that puts all the pieces together.
Any and all feedback is greatly appreciated.
Thanks for reading, and please supplement responsively.
References follow in the immediate post
Last edited:
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