Does it cause hyperplasia?
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Does it cause hyperplasia?
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That's a very vague question. Does it cause hyperplasia where? Do you mean hyperplasia of muscle cells?
Sorry yes in muscle cells ha
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Yes, indirectly.
Mk-677 acts in a way by which it affects the natural inherent secretion of hGH, and consequently IGF-I - which has been proven to cause hyperplastic changes in many tissues, including but not limited to skeletal muscle cells(1)(2)(3)(4)
References
(1)Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart/ Brüel A1, Christoffersen TE, Nyengaard JR / Journal of Cardiovascular Research (2007)
(2)Peripheral activities of growth hormone-releasing hormone/ Granata R1/ Journal of Endocrinilogical Investigation (2016)
(3)Regulation of muscle mass by growth hormone and IGF-I/ C P Velloso/ British Journal of Pharmacology (2008)
(4)Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp/ Li D1, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z/ Journal of Endocrinology (2004)
Knows his shit! Nice!Yes, indirectly.
Mk-677 acts in a way by which it affects the natural inherent secretion of hGH, and consequently IGF-I - which has been proven to cause hyperplastic changes in many tissues, including but not limited to skeletal muscle cells(1)(2)(3)(4)
References
(1)Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart/ Brüel A1, Christoffersen TE, Nyengaard JR / Journal of Cardiovascular Research (2007)
(2)Peripheral activities of growth hormone-releasing hormone/ Granata R1/ Journal of Endocrinilogical Investigation (2016)
(3)Regulation of muscle mass by growth hormone and IGF-I/ C P Velloso/ British Journal of Pharmacology (2008)
(4)Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp/ Li D1, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z/ Journal of Endocrinology (2004)
Interesting! It's great to always learn more about these compounds!Yes, indirectly.
Mk-677 acts in a way by which it affects the natural inherent secretion of hGH, and consequently IGF-I - which has been proven to cause hyperplastic changes in many tissues, including but not limited to skeletal muscle cells(1)(2)(3)(4)
References
(1)Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart/ Brüel A1, Christoffersen TE, Nyengaard JR / Journal of Cardiovascular Research (2007)
(2)Peripheral activities of growth hormone-releasing hormone/ Granata R1/ Journal of Endocrinilogical Investigation (2016)
(3)Regulation of muscle mass by growth hormone and IGF-I/ C P Velloso/ British Journal of Pharmacology (2008)
(4)Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp/ Li D1, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z/ Journal of Endocrinology (2004)
Perfect info right here. This should give you everything you need to know.Yes, indirectly.
Mk-677 acts in a way by which it affects the natural inherent secretion of hGH, and consequently IGF-I - which has been proven to cause hyperplastic changes in many tissues, including but not limited to skeletal muscle cells(1)(2)(3)(4)
References
(1)Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart/ Brüel A1, Christoffersen TE, Nyengaard JR / Journal of Cardiovascular Research (2007)
(2)Peripheral activities of growth hormone-releasing hormone/ Granata R1/ Journal of Endocrinilogical Investigation (2016)
(3)Regulation of muscle mass by growth hormone and IGF-I/ C P Velloso/ British Journal of Pharmacology (2008)
(4)Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp/ Li D1, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z/ Journal of Endocrinology (2004)
Id say from mk677 it would be minimal... youd find far more hyperplastic effect in hgh... or for that matter, igf1. Thats my opinion and I think its pretty accurate.
Ill use a comparison... gains from hcg usage. It can be done at extremely high doses and would be minimally effective compared to running the real deal. . In this example. .. testosterone. Blue shine is correct in his statement but I think the degree to which you would see new cell growth from mk677 use is a bit understated. Not to mention the cost of achieving that level of endogenous production would be very expensive to say the least
So your argument is that mk677 is MORE effective than exogenous hgh? During this head to head it appears that mk677 was given 14 days. I cant see the chart but from what I read and understand a single dose of hgh was given. What was the dosage? What would those numbers look like 14 days after continuation? Im pretty sure from my own experience and that of a handful of close and experienced friends, I can safely say that this study and the conclusion that mk677 is in fact more effective (if that's the conclusion made) is in fact false.... not because I read a writeup about results, but because I saw a different result firsthand... in person.
But thanks for sharing bro. I like this type of conversation/debate... respectful, differing aa it may be
So your argument is that mk677 is MORE effective than exogenous hgh? During this head to head it appears that mk677 was given 14 days. I cant see the chart but from what I read and understand a single dose of hgh was given. What was the dosage? What would those numbers look like 14 days after continuation? Im pretty sure from my own experience and that of a handful of close and experienced friends, I can safely say that this study and the conclusion that mk677 is in fact more effective (if that's the conclusion made) is in fact false.... not because I read a writeup about results, but because I saw a different result firsthand... in person.
But thanks for sharing bro. I like this type of conversation/debate... respectful, differing aa it may be
25mg dosing am... As well as a few friends of mine utilizing the same protocol.... for a few months. I saw almost no real difference in terms of mass building or hyperplasia....
I have been with 3.33 iu everyday now and just recently doubled that to 3.33iu twice daily. In the past few weeks I feel great and have noticed minor changes in body composition but nothing astounding. Its a little too soon to expect anything too notable but im far happier with the results thus far