milk thistle is ok but honestly, its not even that good regardless... tudca is better but the problem here is that far too many do not grasp the concept (and this is not your fault that you were being told this and got bad info) but a methylated oral effects FAR more than just the liver... the liver is a small fraction of the things you need to be concerned about... Blood pressure alone is very scary to cause issue with and that's a major concern, then you have kidneys, lipids, cholesterol, internal organs, the list goes on and on... these ALL need to be addressed and that's why you need an all in one protectant... i prefer CEL cycle assist but there are many good ones out there to choose from... just make sure you are taking care of all these scenarios...