fact or fiction receptor clearing after sarm cycle
- Thread starter blaze91
- Start date
yep.... thats what I was thinking... isn't dnp a fertilizer ?....
Wow man......that's some of the most fucked up logic I've ever heard. First of all you don't ever need to clear your receptors. That doesn't matter if it's steroids or sarms, or whatever. Your androgen receptors NEVER desensitize and are always ready to uptake androgens. That is parroted bro science that's been thrown around for years. What happens on cycle is you do desensitize to the compounds. Which is why you need a little break, but not long from sarms. We always say 2-3 weeks after oct you can start a new sarms cycle, and that works very well
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DNP is not something you'd ever want to fuck with at all. Being a little off on dose can kill you by cooking you from the inside out. Not fun at all
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There are so many YouTube "gurus" out there spitting out bullshit, that I don't doubt it was said somewhere. They are pretty bad overall when it comes to getting bad false information
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Thats why I posted the thread.... To get the facts out there brahs!!
i dont even know what to say.... actually, i want to know where you heard that and from who because i am personally going to take it to this person because that is literally one of the most fucked up, off the wall, extremely dangerous and very very irresponsible and unethical thing to say... that is beyond fucked up and im steaming over it right now
There is absolutely no scientific basis to any of this. But since I'm not a proponent of simply saying something is ridiculous - here's the underlying molecular biology.
1. Nuclear receptors, such as steroid hormone receptors have two molecular conformations. One is bound the other is unbound with respect to their ligand (activator molecule). Receptors don't just "clear" or "dissolve". Some receptors get degraded, but Androgen receptors don't classically behave that way.
2. Receptors have a specific dissociation kinetics. Meaning we can predict the relative percentage of bound to unbound receptors based on the concentration of their ligand. I.e. if you want to reduce the number of bound Androgen receptors you reduce the number of free testosterone/SARMs molecules circulating in the bloodstream.
3. There is always a baseline of ligand to receptor ratio. If you take exogenous testosterone/SARMs and a greater fraction of your Androgen receptors are bound, once you stop, and your testosterone/SARMs levels normalize, you would go back to the physiological ratio of bound to unbound receptors. The receptors don't "clear", they all remain. Their numerical regulation is virtually unaffected by such compounds.
4. Diphenhydramine ("benadrly" in N.America) has nothing to do with the signalling pathways of the Androgen receptor, it acts via Muscarinic and Histaminic pharmacology. DNP has no receptor at all. So even if the entire biology somehow supported this ludicrous theory, those molecules would have nothing to do with normalizing fraction of bound Androgen receptors.
5. Sounds to me like someone has no idea what they are saying, or is recommending a "stack" without really understanding the physiology, endocrinology, pharmacology and biochemistry of... Pretty much anything.
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good fucking lord.. i should have known... these guys are the biggest fucking scum on the planet... this guy is the biggest piece of shit... hes the guy that finds it necessary to make educational videos with women humping in the background etc... oh and the fact him and that other jerk off sell dnp to fucking kids... so yeah, this makes sense and ONLY THESE PIECES OF SHIT would ever say something so fucked up...
this is one of if not the very best explanations ive ever seen when it comes to receptors and getting past all the bull shit that you hear... i am gong to make a video on this because its one of the most misunderstood concepts i run across...
Spot on information bro! Excellent and very detailed!
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I only have 1 kidney Bro.... I wouldn't touch that stuff with a 10 foot pole.... Its good to get this stuff de bunked....
fuck bro, do yourself a major favor and don't listen nor watch those two clowns bro because its just a matter of time before you get severely hurt from their "advice"
MaxxPursuit
Senior Member
Yes... please dont touch dnp man. There isnt a situation that I feel is worth using that compound. What you heard is absolutely twisted and not what you want to follow.
DTA707
Banned
I'm less informed for having watched that. I'm... WTF
the fact anyone ever listens to that fucking PIECE OF TRASH is unreal... i mean he's so fucking low class its insane... that's why they put women and shit like that in their videos and talk about doing extremely crazy shit so they can get viewers and the viewers they get are very young and think that its "cool" and then they get so hurt and sometimes worse... i dont know how they sleep at night doing what they do
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