You're 6'2 280lbs and want to cut down to 225lbs? I'm assuming your bodyfat is highly elevated. I wouldnt cut calories drastically all the way down to 2500 cals. What is your body fat percentage? What does your training/nutrition look like?
Unfortunately, if you actually have gyno from puberty and you've carried it into your mid-20's, surgery is pretty much your only sure method of removal. It's a shot in the dark trying any other protocol which is generally aimed at those who catch it while on cycle.
First time reading it, I skimmed it and thought the question was when to start pct. For bloodwork, I'd suggest waiting 4 weeks before getting it drawn. There are studies that show clomid can linger in your system for around 30 days which can affect results.
If you're not gaining, it's wise to go back to the basics in most cases. Increase food intake and hammer those weights. Simple. No need to overcomplicate things.
Sounds like your metabolism is taking a hit. Dieting for too long. If I were you, I'd reverse diet back up to maintainance for some time to get your metabolism functioning properly first.
Sounds more like he just needs to learn how to eat properly. Stats? Curious what your training and nutrition look like. Gear won't help if you don't have the basics down.
The oral itself is methylated so passing through the liver is where the toxicity is shown. Running test alongside any oral doesn't have any effect on this process.