You mean just generally with anything? That's an open ended question that is impossible to answer. Some people get side effects from certain things and doses right away, and some never get them at all. Others may once it hits peak concentration. There's no way at all to predict this, but obviously higher doses yield more side effects so keep that in mind
bro thats impossible to answer... that completely depends on what your using, what your using for protection, the dosing etc... basically an impossible question... you should be using all your protectants from the start...