BigBusiness
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Exos (active agent - exemestane) is a very strong and very potent steroidal aromatase inhibitor of the suicidal type. Aromatase inhibitors are the compounds that serve to reduce estradiol levels in blood by eliminating the production of estradiol through binding to and disabling the aromatase enzyme, which is responsible for the conversion (or aromatization) of androgens into estradiol. Suicidal aromatase inhibitors serve to permanently inhibit and disable the aromatase enzyme to which it is bound to. This renders the enzyme inactive forever. The body will eventually manufacture more aromatase enzymes, but the currently-bound enzymes are bound indefinitely, eliminating any risk for estrogen rebound. This is the main difference compared alongside two other major aromatase inhibitors: anastrozole and letrozole, which are non-suicidal aromatase inhibitors that are only bound to the aromatase enzyme for limited time periods. If a non-suicidal aromatase inhibitor is halted too abruptly, the circulating inhibited aromatase enzymes that have not been metabolized out of the body will then become free again, and begin aromatizing androgens into estrogens at an often rapid rate. This is not the case with Exos.
Exemestane is a steroidal aromatase inhibitor that doesn't negatively affect your lipids like some other non-steroidal AI’s. It is also not liver toxic, and can be run for longer lengths of time without negative effects. Exemestane also increases IGF-1 levels. There is no estrogen rebound from exemestane, this makes it a better option to run on cycle from a pure health standpoint.
The half-life of Exos is only about 9 hours, and clears quickly. However, because of how effective exemestane is at eliminating aromatase enzymes (80-90% after administration), estrogen levels will remain low up to 72 hours.
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