HTML structures the content, CSS styles it, and JavaScript adds interactivity, collectively shaping a visually appealing and user-friendly website. Optimizing these involves minifying code, leveraging CSS preprocessors for efficient styling, and using asynchronous loading for JavaScript. Ensuring accessibility and adherence to WCAG guidelines involves semantic HTML, proper alt text for images, and keyboard navigation support. Integrating UX/UI principles demands intuitive navigation, consistent design elements, and responsive layouts, prioritizing user needs while coding. Learn more about these strategies in this comprehensive guide on building a website manually: https://syndicode.com/blog/how-to-build-a-website/